ARC-HBR is positive when at least 1 major criterion or at least 2 minor criteria are present.

Major criteria

Minor criteria

Anticipated long-term oral anticoagulation
eGFR <30 mL/min/1.73 m²
Haemoglobin <11 g/dL
Spontaneous bleeding requiring hospitalisation or transfusion within 6 months, or recurrent bleeding
Platelet count <100 × 10⁹/L
Chronic bleeding diathesis
Cirrhosis with portal hypertension
Active malignancy within 12 months, excluding non-melanoma skin cancer
Previous spontaneous intracranial haemorrhage
Traumatic intracranial haemorrhage within 12 months
Brain arteriovenous malformation
Moderate or severe ischaemic stroke within 6 months
Non-deferrable major surgery while receiving dual antiplatelet therapy
Major surgery or major trauma within 30 days before PCI

Age ≥75 years
eGFR 30–59 mL/min/1.73 m²
Haemoglobin 11.0–12.9 g/dL in men or 11.0–11.9 g/dL in women
Spontaneous bleeding requiring hospitalisation or transfusion 6–12 months earlier
Long-term oral NSAID or steroid use
Any ischaemic stroke not meeting the major criterion

Academic Research Consortium High Bleeding Risk (ARC-HBR) Criteria