Total CARG-TT score is the sum of points from 11 pre-chemotherapy variables. Higher scores indicate greater risk of grade 3-5 chemotherapy-related toxicity during the planned regimen.

Variable	Risk category	Points
Age	72 years or older	2
Age	Younger than 72 years	0
Cancer type	Gastrointestinal or genitourinary primary	2
Cancer type	Other primary site	0
First-cycle chemotherapy dose	Standard dose	2
First-cycle chemotherapy dose	Dose reduced upfront	0
Number of chemotherapy drugs	More than 1 drug	2
Number of chemotherapy drugs	1 drug	0
Haemoglobin	Below 100 g/L in women or below 110 g/L in men	3
Haemoglobin	At least 100 g/L in women or at least 110 g/L in men	0
Creatinine clearance	Below 34 mL/min	3
Creatinine clearance	34 mL/min or higher	0
Self-rated hearing	Fair, poor, or totally deaf	2
Self-rated hearing	Excellent or good	0
Falls in past 6 months	1 or more falls	3
Falls in past 6 months	None	0
Ability to take own medicines	Needs some help or unable	1
Ability to take own medicines	Takes medicines without help	0
Walking one block	Somewhat limited or limited a lot	2
Walking one block	Not limited at all	0
Social activity limited by health in past 4 weeks	Limited some, most, or all of the time	1
Social activity limited by health	Not or minimally limited	0

Risk groups are 0-5 low risk, 6-9 intermediate risk, and 10 or higher high risk. The original cohort table reported observed high-risk scores through 19, but the item-sum can reach 23. Scores above 19 should still be treated as high risk.

Cancer and Aging Research Group Chemotherapy Toxicity Tool (CARG-TT)