Group	Criterion	Points
Family history	First-degree relative with premature coronary or vascular disease (men <55 years, women <60 years), or LDL-C >95th percentile	1
Family history	First-degree relative with tendon xanthomata and/or corneal arcus, or child <18 years with LDL-C >95th percentile	2
Clinical history	Patient with premature coronary artery disease (men <55 years, women <60 years)	2
Clinical history	Patient with premature cerebral or peripheral vascular disease (men <55 years, women <60 years)	1
Physical examination	Tendon xanthomata	6
Physical examination	Corneal arcus before age 45 years	4
LDL-C (untreated)	≥8.5 mmol/L	8
LDL-C (untreated)	6.5–8.4 mmol/L	5
LDL-C (untreated)	5.0–6.4 mmol/L	3
LDL-C (untreated)	4.0–4.9 mmol/L	1
DNA analysis	Causative LDLR, APOB or PCSK9 mutation	8

Choose the highest applicable score in each group and sum. Total score >8 = definite FH, 6–8 = probable FH, 3–5 = possible FH, 0–2 = unlikely FH.

Dutch Lipid Clinic Network Criteria for Familial Hypercholesterolaemia