The MASCC risk index is the sum of fixed points for seven baseline factors assessed at onset of febrile neutropenia:

Factor	Finding	Points
Burden of illness	None or mild symptoms	5
	Moderate symptoms	3
	Severe illness or moribund	0
Blood pressure	No hypotension (systolic BP ≥90 mmHg)	5
Chronic obstructive pulmonary disease	No active COPD	4
Tumour type / fungal history	Solid tumour or haematologic malignancy with no previous fungal infection	4
Dehydration	No dehydration requiring parenteral or IV fluids	3
Status at onset of fever	Outpatient at onset of fever	3
Age	<60 years	2

Total score range 0–26. In the original MASCC study, scores ≥21 defined the low-risk group for serious complications.

MASCC Risk Index for Febrile Neutropenia