This tool implements the 2005 International Pediatric Sepsis Consensus Conference definitions for SIRS, sepsis, severe sepsis and septic shock.

Stage	Implemented definition
SIRS	At least 2 of 4 criteria, including abnormal temperature or leukocyte count: Core temperature >38.5°C or <36°C. Tachycardia >2 standard deviations above normal for age, or bradycardia below the 10th percentile in a child aged <1 year, when not explained by external factors. Tachypnoea >2 standard deviations above normal for age or acute mechanical ventilation not due to chronic neuromuscular disease or elective anaesthesia. Leukocyte count elevated or depressed for age, or >10% immature neutrophils, when not due to cytotoxic therapy.
Sepsis	SIRS plus suspected or proven invasive infection.
Severe sepsis	Sepsis plus any of: cardiovascular dysfunction acute respiratory distress syndrome at least 2 non-cardiovascular organ dysfunctions attributable to sepsis
Septic shock	Sepsis with cardiovascular dysfunction despite adequate fluid resuscitation.

Apply the source age-specific heart-rate, respiratory-rate and leukocyte thresholds when deciding whether each criterion is met.

Pediatric SIRS, Sepsis, and Septic Shock Criteria