Pretreatment score = sum of the clinical, serological and histological points below. Add treatment-response points only for the post-treatment score.

Feature	Category	Points
Sex	Male	0
Sex	Female	+2
ALP to AST or ALT ratio	<1.5	+2
ALP to AST or ALT ratio	1.5–3.0	0
ALP to AST or ALT ratio	>3.0	−2
Serum globulins or IgG	>2.0 × ULN	+3
Serum globulins or IgG	1.5–2.0 × ULN	+2
Serum globulins or IgG	1.0–1.5 × ULN	+1
Serum globulins or IgG	<1.0 × ULN	0
ANA, SMA or LKM-1 titre	>1:80	+3
ANA, SMA or LKM-1 titre	1:80	+2
ANA, SMA or LKM-1 titre	1:40	+1
ANA, SMA or LKM-1 titre	<1:40 or negative	0
AMA	Positive	−4
AMA	Negative	0
Hepatitis A, B and C viral markers	Positive	−3
Hepatitis A, B and C viral markers	Negative	+3
Hepatotoxic drug exposure	Yes	−4
Hepatotoxic drug exposure	No	+1
Average alcohol intake	<25 g/day	+2
Average alcohol intake	25–60 g/day	0
Average alcohol intake	>60 g/day	−2
Histology	Interface hepatitis	+3
Histology	Predominantly lymphoplasmacytic infiltrate	+1
Histology	Hepatocyte rosettes	+1
Histology	No typical AIH histology	−5
Histology	Biliary changes suggesting PBC or PSC	−3
Histology	Other changes suggesting a different cause	−3
Other autoimmune disease	Present in the patient or a first-degree relative	+2
Other defined autoantibodies	Present when ANA, SMA and LKM-1 are negative	+2
HLA DR3 or DR4	Present	+1
Treatment response	Not treated or not assessed	0
Treatment response	Complete response	+2
Treatment response	Complete response with relapse	+3

Pretreatment: 10–15 points = probable AIH and >15 = definite AIH. Post-treatment: 12–17 points = probable AIH and >17 = definite AIH.

Revised Original Score for Autoimmune Hepatitis (AIH)