Inputs are converted to the reference units before calculation. Define A = age − 73 years, B = systolic blood pressure − 150 mmHg, T = total cholesterol − 6 mmol/L, H = HDL cholesterol − 1.4 mmol/L, D = 1 when diabetes is present and 0 otherwise, and S = 1 for current smoking and 0 otherwise.

The sex-specific linear predictor uses A, D, S, B, T and H plus the interactions A × D, A × S, A × B, A × T and A × H with the published SCORE2-OP coefficients.

Sex	Offset	Baseline survival
Male	0.0929	0.7576
Female	0.2290	0.8082

Uncalibrated risk U = 1 − baseline survival^{exp(linear predictor − offset)}. Let Z = ln[−ln(1 − U)]. The selected regional risk is 100 × {1 − exp[−exp(a + b × Z)]}.

Sex	Risk region	a	b
Male	Low	−0.34	1.19
Male	Moderate	0.01	1.25
Male	High	0.08	1.15
Male	Very high	0.05	0.70
Female	Low	−0.52	1.01
Female	Moderate	−0.10	1.10
Female	High	0.38	1.09
Female	Very high	0.38	0.69

Displayed category	10-year risk
Low	< 2%
Moderate	2% to < 10%
High	10% to < 20%
Very high	≥ 20%