SOFA-2 total is the sum of six 0–4 point domains, for a total of 0–24.

Domain	0 points	1 point	2 points	3 points	4 points
Brain	GCS 15 or clear command gesture	GCS 13–14, localises to pain, or delirium drug treatment	GCS 9–12	GCS 6–8	GCS 3–5, extension/no response to pain, or generalised myoclonus
Respiratory	PaO2/FiO2 above 300 mmHg	300 or lower	225 or lower	150 or lower with advanced support	75 or lower with advanced support, or ECMO
Cardiovascular	MAP at least 70, no agent	MAP below 70, no agent	Norepinephrine + epinephrine at most 0.2; dopamine alone at most 20; or any single other agent	Norepinephrine + epinephrine above 0.2 through 0.4; dopamine alone above 20 through 40; or low dose plus another agent	Norepinephrine + epinephrine above 0.4; dopamine alone above 40; medium dose plus another agent; or mechanical support
Liver bilirubin	At most 1.20 mg/dL	Above 1.20 through 3.0	Above 3.0 through 6.0	Above 6.0 through 12.0	Above 12.0
Kidney	Creatinine at most 1.20 mg/dL and no oliguria threshold	Creatinine above 1.20 through 2.0, or oliguria 6–12 h	Creatinine above 2.0 through 3.5, or oliguria at least 12 h	Creatinine above 3.5, prolonged severe oliguria, or anuria	Receiving or meeting criteria for renal replacement therapy
Haemostasis platelets	Above 150 ×10³/µL	101–150	81–100	51–80	50 or lower

Sequential Organ Failure Assessment (SOFA)-2 Score