SOFA total is the sum of six organ-system subscores, each 0–4 points; total range 0–24. Use the worst value from the defined observation window.

Domain	0 points	1 point	2 points	3 points	4 points
Respiratory, PaO2/FiO2	At least 400	Below 400	Below 300	Below 200 with respiratory support	Below 100 with respiratory support
Coagulation, platelets ×10⁹/L	At least 150	Below 150	Below 100	Below 50	Below 20
Liver, bilirubin	Below 1.2 mg/dL	1.2–1.9	2.0–5.9	6.0–11.9	Above 12.0
Cardiovascular	MAP at least 70	MAP below 70	Dopamine at most 5 or any dobutamine	Dopamine above 5 through 15, or epinephrine/norepinephrine at most 0.1	Dopamine above 15, or epinephrine/norepinephrine above 0.1
Neurological, GCS	15	13–14	10–12	6–9	Below 6
Renal, creatinine or urine output	Below 1.2 mg/dL or below 110 µmol/L	1.2–1.9 mg/dL or 110–170 µmol/L	2.0–3.4 mg/dL or 171–299 µmol/L	3.5–4.9 mg/dL or 300–440 µmol/L, or urine below 500 mL/day	At least 5.0 mg/dL or above 440 µmol/L, or urine below 200 mL/day

For the renal domain, use whichever of the creatinine category or 24-hour urine output gives the higher subscore.

Sequential Organ Failure Assessment (SOFA) Score